From: Misha Gromov Sent: Sunday, May 15, 2016 8:25 AM To: Jeffrey E. Subject: Re: 50/50 is generous; also will make me more involved if you ta=e it. the erson I s oke to is Victoria Nik=forova below is the (rather long) summary/advertisement she sent me=on my request We plan to bring to the healthcare marke= what we call a HealthSpan Pass — an individual rec=mmendation (an individually designed healthcare pathway) on molecular adju=tments for healthy ageing and healthspan extension, based on simultaneous =nalysis of near all molecules (comprising a human metabolome) in a microsa=ple of blood by metabolomics approach being imposed on our academic expert-se in molecular metabolism of ageing. In the production workflow we utilise bl=od metabolomics technology for identification of the molecular changes ass=ciated with ageing and biomarkers of age-related disorders. Current and pa=t medicinal interventions, individual lifestyle habits and dietary prefere=ces are also reflected in a molecular composition of blood as a universal =etabolic information integrator. From such analysis imposed on our know-wh= on human molecular metabolism, we are able to determine the impact of par=icular metabolites on the developmental trajectory of healthy agei=g, to diagnose pre- pathological healthspan violations and to indi=ate the precise molecular targets for personalised fine tuning of ageing metabolism. Additionally, to expand availability of our ser=ice and to make it distance-independent, we plan to develop a self=sampling device compatible with our technological metabolomics pl=tform, and to bring it to a medical self-care market as a valuable side pr=duct. In the developmental process of our main=product HealthSpan Pass, two more add-value side products will be created:=UniMetaMarker (universal metabolic biomarker panel) and c=trong>AgeMetaMarker (healthspan metabolic biomarker panel). A bio=arker panel is a set of molecules, selected from human metabolom