HOUSE OVERSIGHT 025157 THE INTERACTIVE BRAIN (working title) By V.S. Ramachandran [US — Penguin Press, Audio — Penguin RH; Proposal; Delivery: 24 months from signed contract; 60,000 — 70,000 words] A new book by neuroscientist V.S. Ramachandran, author most recently of The Tell-Tale Brain. "The Interactive Brain," writes Ramachandran, "is a tour of some of the most cherished yet elusive qualities of our minds. The book argues that recent advances in neurosciences have contributed to a revolutionary new model of the brain, in which brain function is controlled, not by highly specialized, hierarchical modules, mainly hard-wired, as once thought, but rather by highly interactive modules that can shift their roles in a matter of days or even hours The implications are not merely theoretical but have practical applications in medicine, offering solutions for everyone from stroke patients to those with obsessive compulsive disorder. "There are many neurological syndromes I'll discuss throughout the book. For example, a patient who was otherwise smart and level-headed but kept insisting that his reflection in the mirror was the 'real David,' and that the David viewing the mirror was a clone. He wiped off a tear from his eye and asked 'Dad, if the real David returns will you disown me?' Even the axiomatic foundation of our selfhood—the notion that I'm a single person in one body—is called into question when we encounter patients like him. "Not only can we change our own brains, but we can change the brains of others because of the implications of mirror neurons. The Interactive Brain incorporates case studies, such as David's, and my own research on topics ranging through Capgras Syndrome, chronic pain, calendar synesthesia, gender incongruity, mirror visual feedback, and obsessive-compulsive disorder, the majority of which I have not considered in detail in my previous books. "I conclude by visiting some of the most prized but elusive aspects of our