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ACKRELL CAPITAL Cannabis Investment Report | December 2017 (4) FDA Routinely Approves CBD Drugs The FDA will adopt procedures for the routine approval of drugs that contain extracts of certain low-THC/high-CBD FDA-registered chemovars. The new procedures will involve development of a low-THC cannabis drug monograph that resembles in some ways the FDA monographs for over- the-counter drugs. The monograph will address formulation, dosing and labeling requirements. The FDA-registered chemovars included in the monograph will be rescheduled by the DEA to Schedule II, HI, IV or V in order to relax DEA registration requirements for manufacturing; however, the chemo- vars themselves (particularly their flowers) will not be approved for use by the FDA, and only drugs produced from extracts in accordance with the monograph will receive routine FDA approval. (5) FDA Routinely Approves THC Drugs Relying on experience with the low-THC cannabis drug monograph and a growing database of FDA- registered chemovars, the FDA will adopt procedures for the routine approval of drugs that contain extracts of certain high-THC FDA-registered chemovars. The procedures will parallel in many ways those used in the low-THC monograph procedure, and likely will incorporate additional safeguards related to THC content. The FDA-registered chemovars included in the high-THC monograph will be rescheduled by the DEA, but cannabis flower from those rescheduled chemovars will not be approved for use by the FDA. (6) Federal Government Legalizes Cannabis Parts and derivatives of the cannabis plant will be removed from the CSA schedules. This could occur incrementally, starting with CBD (which could be removed by amending the definition of marijuana to exclude CBD) and followed later by the rest of the plant (including THC). Or all parts and deriv- atives of the plant could be de-scheduled at the same time. There will be three general categories of legal cannabis products: (i) FDA-approved drugs, which will

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