ACKRELL CAPITAL Cannabis Investment Report | December 2017 The Path to Federal Legalization We believe that the variable which will most impact the future size of the U.S. legal cannabis mar- ket is the federal legalization process. How and when federal legalization occurs will impact other primary drivers of the market, including the number of eligible consumers, penetration rates and consumer spending. We predict six developments relating to federal legalization: (1) the U.S. Food and Drug Administration (FDA) will begin approving individual pharmaceutical-grade drugs derived from cannabis; (2) more states will adopt medical cannabis laws; (3) more states will adopt recre- ational laws; (4) the FDA will adopt routine approval procedures for drugs with extracts of low-THC/ high-CBD cannabis varieties; (5) the FDA will adopt routine approval procedures for drugs with extracts of high-THC cannabis varieties; and (6) cannabis parts and derivatives will be removed from the CSA schedules (either incrementally, starting with CBD, or all at once) and will be fully legal for medical and recreational purposes. (We expand on these predicted developments in Chapter IV, U.S. Legal Landscape.) We do not predict that these developments necessarily will occur in the order presented. We do expect some of them to develop in parallel, and none of them depends fundamentally on any other. For example, Congress could cause development (6) at any time by passing legislation that removes cannabis from the CSA schedules and establishes Path to Federal Legalization a national framework for recreational and medical 1. The U.S. Food and Drug Administration will cannabis regulation. Developments (1) through (3) begin approving individual pharmaceutical: | largely reflect incremental developments within grade drugs derived from cannabis. the existing legal environment. We do not expect 2. More states will adopt medical cannabis developments (4), (5) or (6) to occur during the laws. current