New Leaf Ventures I, L.P. $ amounts in millions, as of March 31, 2014 Please refer to Endnotes 1,J,K,L,M and N in this Appendix. Gross Multiple Gross Vintage Realized Unrealized Total (Realized Multiple Company Sector Year Total Cost Value Value Value Portion) (Total) Gross IRR Aesthetic Sciences Corporation Healthcare Devices 2006 $ 41 $ 2 $ = $ = 2 = NM Artisan Pharma, Inc. Therapeutics 2006 $ 10.8 $ = $ = $ 2 = = NM Aviir, Inc. Diagnostics & Infrastructure 2007 $ 163 $ 0.9 $ = $ 0.9 0.05 0.05 NM Barrier Therapeutics, Inc. Therapeutics 2006 $ 8.2 §$ 64 $ - $ 64 0.78 0.78 -11.8% BioRelix, Inc. Therapeutics 2007 $ 63 §$ = $ = $ 2 = = NM Cerexa, Inc. Therapeutics 2005 $ 8.0 $ 43.4 §$ - $ 43.4 5.42 5,42 197.3% CN Therapeutics, Inc. Therapeutics 2006 $ 01 $ = $ = $ - = = NM Interlace Medical, Inc. Healthcare Devices 2005 $ 7.8 $ 67.3 §$ 01 $ 67.4 8.62 8.64 84.4% Oriel Therapeutics, Inc. Therapeutics 2007 $ 11.1 $ 18.8 $ 12.2 $ 31.0 1.70 2.80 49.9% Pearl Therapeutics, Inc. Therapeutics 2007 $ 28.9 §$ 72.3 $ 173 $ 89.6 2.50 3.10 33.1% Proteogenix, Inc. Diagnostics & Infrastructure 2007 $ 94 §$ 08 $ = $ 0.8 0.08 0.08 NM Stromedix, Inc. Therapeutics 2008 $ 10.7 $ 19.2 $ 22.5 $ 41.7 1.79 3.89 42.0% Transcept Pharmaceuticals, Inc Therapeutics 2005 $ 15.6 $ 71 $ - $ 71 0.46 0.46 -11.5% Total Realized or Partially Realized Investments $ 13.7 §$ 236.2 §$ 52.1 §$ 288.3 Lay 2.10 27.5% Access Closure, Inc. Healthcare Devices 2006 $ 24.7 $ - $ 35.4 $ 35.4 - 1.43 6.1% Concert Pharmaceuticals, Inc. Therapeutics 2006 $ 6.2 $ - $ 6.8 $ 6.8 - 1.11 1.5% Direct Flow Medical, Inc. Healthcare Devices 2005 $ 13.0 $ - $ 20.2 $ 20.2 - 1.56 7.1% IltuminOss Medical, Inc. Healthcare Devices 2008 $ 10.1 $ - $ 9.7 §$ 9.7 - 0.97 -0.8% Intarcia Therapeutics, Inc. Therapeutics 2007 $ 36.9 § - $ 186.9 §$ 186.9 - 5.06 39.9% Relypsa, Inc. Therapeutics 2007 $ 23.7 $ - $ 61.8 $ 61.8 - 2.60 27.5% ReShape Medical Healthcare Devices 2006 $ 13.6 $ - $ 13.7 $ 13.7 - 1.01 0.2% Tioga Pharmaceuticals, Inc. Ther