For “human subject research,” we refer to the 1964 Declaration of Helsinki, keeping in mind the 1932-1972 Tuskegee syphilis experiment, possibly the most infamous biomedical research study in U.S. history. In 2015, the Nonhuman Rights Project filed a lawsuit with the New York State Supreme Court on behalf of two chimpanzees kept for research by Stony Brook University. The appellate court decision was that chimps are not to be treated as legal persons since they “do not have duties and responsibilities in society,” despite Jane Goodall’s and others’ claim that they do, and despite arguments that such a decision could be applied to children and the disabled.*° What prevents extension to other animals, organoids, machines, and hybrids? As we (e.g., Hawking, Musk, Tallinn, Wilczek, Tegmark) have promoted bans on “autonomous weapons,” we have demonized one type of “dumb” machine, while other machines—for instance, those composed of many Homo sapiens voting—can be more lethal and more misguided. Do transhumans roam the Earth already? Consider the “uncontacted peoples,” such as the Sentinelese and Andamanese of India, the Korowai of Indonesia, the Mashco- Piro of Peru, the Pintupi of Australia, the Surma of Ethiopia, the Ruc of Vietnam, the Ayoreo-Totobiegosode of Paraguay, the Himba of Namibia, and dozens of tribes in Papua New Guinea. How would they or our ancestors respond? We could define “transhuman” as people and culture not comprehensible to humans living in a modern, yet un-technological culture. Such modern Stone Age people would have great trouble understanding why we celebrate the recent LIGO gravity-wave evidence supporting the hundred-year-old general theory of relativity. They would scratch their heads as to why we have atomic clocks, or GPS satellites so we can find our way home, or why and how we have expanded our vision from a narrow optical band to the full spectrum from radio to gamma. We can move faster than any other living species; indeed, we can r