NAUTILUS EDUCATION | BETA PRODUCT Genetics & Hi Health Since DNA 1s often heralded as the “code of life,’ what clues can mutations—changes to the DNA sequence—tell us about human health and disease? The pair of articles in the Genetics and Human Health module will explore the consequences of mutations in the context of cancer treatment and rare diseases such as muscular dystrophy. 7heir Giant Steps to a Cure discusses the challenges associated with treating a rare form of muscular dystrophy. An Unlikely Cure Signals Hope for Cancer explores how specific mutations in a patient’s cancer can be used to a patient’s advantage. Lesson Plan Ask students to read both of the articles for homework. Briefly introduce or review the vocabulary words in class. Assign the questions listed under “Reading Comprehension” for them to complete along with the reading and ask them to come up with one question for further discussion. Start class by asking students if they have any questions about the readings. Ask them to contribute their discus- sion questions (in addition to the ones provided under Deep Thinking / Discussion questions). Have the class brainstorm and answer both discussion questions. 15 MIN. Next, break the class up into four groups for the Suggested Activity. Assign each group to one protein that 1s listed in the interactive. 15 MIN. Have each group present their thoughts to the class for further discussion. 15 MIN. Teacher’s Notes: Their Giant Steps to a Cure, and An Unlikely Cure Signals Hope for Cancer VOCAB WORDS Muscular dystrophy: a genetic disease marked by of proximal (limb-girdle) muscles. p eculeg dh a eeu a ase Pee Cancer: A term used to describe disease in which a od e : abnormal cells divide without control and are able to Orphan diseases: diseases that have yet to be “adopt- invade into other tissues. Cancers are often catego- ed” by the pharmaceutical industry because there are rized based on the organ or cell type they originate in. VenyIew Incenlivest