Applied Viruses - Please do not redistribute. Contact: Alexandra Treschow APPLIED VIRUSES INC. "Software for Life" version 1/24/2012 PRELIMINARY BUSINESS AND STRATEGIC PLAN Applied Viruses is a biotechnology company aiming to lead synthetic virology, a new field founded on the computer-assisted design and manufacture of synthetic viruses. Synthetic viruses are the biological equivalent of computer software. Installed and booted in a permissive host cell, they can take control over virtually any cellular function, including the self-manufacture of more viruses. They make excellent drug delivery, antibiotic, and anti-cancer agents today and in future will become even more programmable and versatile, opening a wide range of product development possibilities. Problem Bioengineering, particularly new drug development, takes too long and costs too much. Solution Synthetic biology is the computer-assisted design and synthesis of biological systems. It makes biology much easier and cheaper to engineer. Viruses, with small genome sizes and broad versatility, are relatively simple and fast to design and manufacture. They are poised to become the "apps" of biology and be at forefront of the synbio revolution. Mission Make synthetic viruses. Specifically, develop, manufacture, market, and support synthetic lytic viruses that have immediate utility in the medical, veterinary, and environmental marketplace. Create a high-throughput virus assembly line (virus "biofab") with read-write (sequencing- synthesis) capability for in-house and external use. Attract and develop a technical viral design community. Maintain leadership in synthetic virology. Objectives Strategy: Build a general-purpose, flexible virus assembly line, demonstrate design-build-test capability, understand and optimize with synthetic phage, advance to eukaryotic viruses, build virus design expertise and cultivate crowdsourced virological talent, revolutionize biotechnology industry. Pr