From: Ting, Jess Sent: Wednesday, February 20, 2013 12:07 PM To: Jeffrey Epstein Subject: Re: Research Wow. That is incredibly generous of you!!! We cannot thank you enough. We =ill keep you apprised if progress in the project. I truly believe that you= contribution will be looked upon someday as enabling major progress in ca=cer pathogenesis. I will get you the details shortly. Jess Ting On Feb 20, 2013, at 6:37 AM, "Jeffrey Epstein" <[email protected]<[email protected]» wrote: I will send the 50 k. need details.on entity ( tax id. etc. ). glad to=be of help On Tue, Feb 19, 2013 at 5:30 PM, Ting, Jess wrote: Our research is based on the hypothesis that it is the micro-environment (e=g., the "normal" breast tissue surrounding a breast cancer in the case of =reast cancer) that enables tumors to metastasize - rather than something i=trinsic to the tumors. There is much anecdotal evidence to support this an= it also explains several paradoxes about breast cancer - for example, why=extirpative surgery for breast cancer seems to cause a paradoxical rise ca=cer activity. This theory which is known as the "seed and soil" hypothesis=has been purely theoretical in the past because until now there was never =ay to study the microenvironment around these tumors without killing the h=st or killing the tissue itself. We came up with the idea to use fluid that is routinely collected (but thro=n away) for 1-2 weeks after breast surgery as a proxy for the microenviron=ent around the tumor. Let me explain - after breast surgery to remove a c=ncerous breast, we routinely place a plastic drainage tube in the wound be= which exits the skin and drains excess blood and wound fluid into small p=astic reservoirs. This prevents buildup of unwanted blood and fluid after =urgery. This fluid is thrown away. The drains are kept in for a week or tw=. Our idea was that this fluid contains all the proteins, growth factors, =ytokines, DNA transcription facto