Citrus AntiFatigue Powder Study Proposal With approximately 14 million cancer survivors today in the United States alone, increased attention is being given to the quality of life of our cancer patients both during and after treatment. Cancer related fatigue (CRF) is the most common, and one of the most devastating symptoms among patients with cancer (Bruera, 2012). According to the National Comprehensive Cancer Network, CRF is defined as a "persistent, subjective sense of physical, emotional, and/or cognitive exhaustion related to cancer or its treatment that is not proportional to recent activity" (NCCN, 2008). CRF has been rated as having a greater negative impact on quality of life than other cancer-related symptoms such as pain, depression, and nausea (Hoffman, 2007). In addition, CRF has a negative impact on all areas of function, including mood, physical function, work performance, social interaction, family care, cognitive performance, schoolwork, and community activities (Berger, 2009; Bower, 2005; NCI, 2010). Unfortunately, clinically meaningful, evidence-based treatment options for CRF are extremely limited. A supplement that can be taken orally to mitigate CRF would represent a tremendous contribution towards the care of our patients affected with cancer and potentially for people with other causes of fatigue. A recent phase III clinical trial found a statistically significant improvement in fatigue after 4 weeks of American ginseng. This pilot study seeks to evaluate the viability of Citrus AntiFatigue Powder for CRF. Objective: To determine if Citrus AntiFatigue powder is effective in improving CRF as measured by the FACIT-F and the PROMIS Item Bank — Fatigue — Short Form. Design: Randomized placebo-controlled pilot study Setting: Comprehensive outpatient cancer center EFTA01192266