From: To: Jeffrey Epstein <[email protected]> Subject: Fwd: article from Ed Boyden on using gamma frequency stimulation to attenuate amyloid load Date: Thu, 20 Jul 2017 11:47:15 +0000 Attachments: nature20587.pdf Currently the optogenetics stuff is extracranial and very invasive Might be better to approach endovascular / noninvasive Begin forwarded message: From: Philip Eckhoff Date: July 20.2017 at 5:38:14 AM GMT+1 To: Dear all, > Subject: article from Ed Boyden on using gainma frequent) stimulation to attenuate amyloid load Each year I interview about half of the finalists for the Hertz Fellowship, and one of my co- interviewers is Ed Boyden at MIT. Over lunch between interviews, it is always fun and fascinating to hear about what he is working on at present. This past spring, one of the projects I heard about was about stimulating gamma oscillations in mice brains and the corresponding impact on amyloid load and plaque formation (and microglia). They did it optogenetically and saw a strong effect at 40 Hz, and then they did it just with flickering light at 40 Hz. Pretty cool result, and will be interesting to see where it goes. http://www.nature.comMature/joumal/v540/n7632/full/nature20587.html Paper attached. Best, Philip EFTA01039994