From: "jeffrey E." <jeevacationggmail.corn> To: Subject: Re: confidential please Date: Tue, 19 Sep 2017 11:00:11 +0000 side effects? On Mon, Sep 18. 2017 at 6:11 PM wrote: here is the concept i am discussing w arch capital today and then w third rock and voyager on thursday and friday. i will also go visit the scientists that harvest and inject mitochondria at harvard (hearts only). oxygen and energy are the two highest order system issues - nonspecific to just add oxygen or energy but it works for everything. doesn't fix underlying problem but does buy time, improve function and prevent greater damage from certain injuries if caught quickly. i think it can change the game big time in the neuro space. Mitochondrial transplantation in the human brain Idea Mitochondrial transplantation is based on the delivery of isolated, viable mitochondria to the target organ to restore bioenergetic function. I believe we can augment or replace mitochondria in the brain damaged by ischemia/aging/disease as a mechanism to enhance cellular function and cellular rescue. Feasibility • Human trials underway elsewhere. 2016 heart trials effective - cardiac, skeletal muscle, pulmonary & hepatic tissue + neuronal • Augments a natural process. Glial/neuronal bidirectional organelle transfer, retrograde axonal recycling • Known delivery mechanisms. Accessible directly or via arterial endovascular • Known outcomes in other organs with similar bioenergetic demands. Cardiac trial results show that 10 min following mitochondria] transplantation myocardial function is significantly enhanced as compared to hearts receiving EFTA01018509