From: "jeffrey E." <[email protected]> To: Lesley Groff <1 Subject: Re: Joe Thakuriamti Date: Thu, 05 Jun 2014 19:43:45 +0000 Mine first the fund On Thursday, June 5, 2014, Begin forwarded message: From: Joseph Thakuria Subject: Re: Jeffrey Epstein Date: June 5. 2014 at 3:34:41 PM EDT To: Lesley Groff <I > wrote: Sony for the delayed response. We just got word from the IRB and we're finally ready to push forward with the YPO study. I wanted to discuss a couple things with Jeffrey by phone at his convenience including: a) getting a whole genome through Illumina puts him a little bit outside of the workflow pipeline for the YPO project. le, those participants are paying $1000 each and will be getting their exomes sequenced through Ambry, a thumbnail drive of their compressed genomic data, and an annotated report of 56 ACMG gene hits. I think it's worth getting him into this queue as well so he goes through the same pipeline as the YPO folks and others in our study. Last time I discussed with him he definitely wanted a whole genomes through Illumina for —$11,000 (which is still fine) but would he be interested in also getting the $1000 exome to also go through the normal pipeline? Although the exome data should be redundant with the whole genome data, I think it's worth it for the thumbnail drive and the ACMG gene summary. We'll also be able to check for concordance between the 2 datasets. b) Jeffrey has samples (including fibroblast cell culture from his skin biopsy) at HMS. Do I have his permission to request these samples from the PGP for inclusion in the YPO study? (The samples can be used for both studies if he wishes.) Our YPO study may need a self-collected saliva sample for which I can mail him a kit. So, I wanted to discuss these sample issues with him as well. c) Lastly, we actually still need some bioinformatic and genetic counselor support for the YPO study - not just for his sample but all of our 80 plus YPO study subjects