From: To: Jeffrey Epstein <[email protected]> Subject: Funding Proposal Date: Sat, 14 Mar 2015 19:18:21 +0000 Attachments: telomere_article.docx Hi Jeffrey, I would like to be a scout for the foundation to pick the best research projects in the fields that interest you. Below is the beginning of a funding proposal. It suggests 3 innovative, current, research projects in Alzheimer's, Cancer (pathway resistance) and Age regeneration. I've also attached a supporting article I wrote on the aging research. I like the cancer project because it ties into Martin Nowak's work. I look forward to discussing this with you. all the best, Alzheimer's Dr. Berislav Zlokovic, MD, PhD Director, Zilkha Neurogenetic Institute Professor and Chair, Department of Physiology & Biophysics Director, Center for Neurodegeneration & Regeneration Zilkha Neurogenetic Institute Keck School of Medicine of USC 1. Recent research shows a major correlation between Alzheimer's and leaks in the blood brain barrier: Zlokovic's team compared brain scans from 63 people of different ages taken with magnetic resonance imaging, or MRI. The MRI scans tracked an element called gadolinium in healthy people aged 23 to 91 years old. Gadolinium serves as a marker to track where blood flows. Zlokovic's team watched as it passed through the blood-brain barrier. The barrier's leakiness first showed up in the hippocampus. And leaks were more likely to show up in older brains. People 55 to 85 years old with some memory problems had leakier blood-brain barriers than healthy people their age. Zlokovic's team reported its new findings on January 21 in the journal Neuron. 2. Alzheimer's and a genetic excess of Cyclophilin A: People who carry two copies of the ApoE4 gene have approximately 8 to 10 times the risk of getting Alzheimer's than those who do not have the gene. Scientists from Rochester University and the University of Southern California have shown how ApoE4 can unleash an exces