From: Eva Dubin To: Jeffrey <[email protected]> Subject: FW: Let's discuss Date: Tue, 01 Apr 2014 14:29:31 +0000 Importance: Normal From: To: Subject: Let's discuss Date: Tue, 1 Apr 2014 14:25:17 +0000 Jeffrey Epstein, Mount Sinai Patron, Backs Major Discovery for Triple Negative Breast Cancer The Jeffrey Epstein VI Foundation funds major discovery to combat triple negative breast cancer. PR Newswire NEW YORK, March 31, 2014 NEW YORK, March 31, 2014 /PRNewswire/ — Triple negative breast cancer is a particularly aggressive form of breast cancer, highly metastatic and causes about 20% of breast cancer incidences worldwide. Unlike estrogen or progesterone cell surface receptor- type breast cancers, isolating an effective receptor for triple negative breast cancer has yet to be found—to develop a blocking molecule or inhibitor. Recently however, a renowned medical team collaborating with the Icahn School of Medicine at Mount Sinai in New York City and with the ongoing support of science philanthropist, Jeffrey Epstein, have identified a possible triple negative receptor to target for blocking. Published in the journal Cancer Cell, the research team used several mouse models to see what predominantly fueled the growth of triple negative breast tumor cells. The study revealed that the tumor cells were heavily dependent on, and fueled by increased levels of cytokines and chemokines, proteins which play a key function in balancing immune responses and cell signaling. The study then went a step further and tested a preliminary molecule to block the cytokine pathway. So far the therapy has shown promising results on causing triple negative necrosis or cell death. 'Finding a unique receptor for triple negative breast cancer has been an elusive battle,' Jeffrey Epstein remarked, whose foundation, the Jeffrey Epstein VI Foundation provides ongoing funding to Mount Sinai's work. 'Isolating the pathways that regulate cytokines and chemokines could