From: george church < > To: "Jeffrey E." <[email protected]> Subject: Re: value Date: Fri, 11 Jul 2014 21:04:58 +0000 Jeffrey, Many thanks for your very encouraging words yesterday morning. This is already a super interesting experiment (even with $0 spent), since I am looking at my whole ecosystem of companies and unassigned inventions totally differently. Eye-opening to see how accustomed one can become to the assumptions, whims and rules of VCs. For example, investors starting Helicos took Eric's advice over mine in 2003 (even though he had zero sequencing technology invention experience and I had 26 years) -- so rather than a large founder's share in a new company (Helicos), my technology dribbled into an established company (CGI) from 2006-2012. CGI was sold for $117M in 2012, while Helicos went bankrupt. Below is a first pass list of potential investments for the $10M. This may be more information than you wanted at this point (especially given the trade-off between jargon and brevity), but I'm having so much fun, I just wanted to share it. I'm also recording a few extra thoughts, in case they provide "teaching moment" or post-mortem at some point. $200,000 $1,500,000 $1,000,000 Sensor-Selectors $1,000,000 Protein stability & virus resistance $1,000,000 Pest control $800,000 Aging reversal $1,550,000 Next generation pathology $250,000 Space Genetics $200,000 Cold-resistant elephants $2,500,000 2nd tranche $10,000,000 Total 1) Thirty genomes collected so far on a small budget by James Clement. $200K would get 8% ownership of the company and allow another 30 genomes to be collected, sequenced and therapies patented. 2) Using CRISPR to engineer animals for resistance to infectious diseases and to act as transplantation donors for major organs (initially kidneys) to humans. Co-founded with Prashant Mali and Luhan Yang. Already has a couple of contracts and a some rented lab space. 3) Sensor-selector technology for op