From: Jeffrey Epstein <[email protected]> To: Subject: Re: Joe Thakuria Date: Mon, 24 Feb 2014 20:44:46 +0000 lets start and do the full genome with rapid turn around. 11, 400 On Mon, Feb 24, 2014 at 4:41 PM, Begin forwarded message: From: Joseph Thakuria Subject: Re: Jeffrey Epstein Date: Februa 24, 2014 3:38:36 PM EST To: Cc: Rich Kahn Hi Lesley and Rich, Lesley, can you forward the following info to Jeffrey? > wrote: So when I sent the initial invoice I didn't have the actual whole genome costs through Illumina which are $9500 for a normal turn around time and $11,400 for "rapid turn around time". The rapid turn around time isn't necessary in Jeffrey's case. And, in my opinion, if the budget is only $5000, I think the most bang for his buck (and this is what I would do for myself with only $5000 to spend) is to get an exome done. I should be able to get this through Ambry and through the same research protocol we'll be suing for the YPO study participants for $1000. I would then use the remainder to purchase genome analyses tools (there won't be enough for any servers) to perform secondary analyses on the exome. The exome only represents around 1.5% of the genome - but this is the medically most important part of the genome (at least given our current knowledge) and represents all the coding regions in all our 20,000+ genes. If this sounds good to Jeffrey, I'll produce a final budget before the end of the week that specifies which of the tools we'll be able to get with the remaining $4000. (I need to finish pricing and tallying up features among the 6 I listed to determine which one(s) will get. This won't of course cover any cellular work or other items in the full invoice but I would still recommend moving at least some fibroblast cell lines aliquots from the PGP to our new study so we can work on those when funding from other sources is available. I would also just throw out there for Jeffrey's consideration that the same ambi